Can you mix diazepam and flexeril?

Mixing diazepam (a benzodiazepine) and Flexeril (metaxalone) can be potentially dangerous. Flexeril can lower the seizure threshold, while diazepam can lower CNS activity and increase the risk of respiratory depression. When these two medications are used together, the depressant effects of both drugs can be enhanced. This can increase the risk of side effects such as dizziness, drowsiness, respiratory depression, and confusion. Mixing these medications can also be fatal. Therefore, it is generally not recommended to combine diazepam and Flexeril without first consulting a healthcare professional.