What Is the CB2 Receptor Agonist?

The CB2 agonist is a cannibinoid molecule capable of stimulating CB2 receptors. Research into the therapeutic efficacy of the cannibinoid---a chemical compound found in cannibis and marijuana---has been of interest because it carries many of the beneficial effects of marijuana without the intoxicating psychoactive properties.

Anti-inflammatory Mechanism

• An agonist, according to MedicineNet.com, is a "drug that binds to a receptor of a cell and triggers a response by the cell." It often "mimics the action of a naturally occurring substance."

  The CB2 receptor agonist shows wide expression in peripheral immune cells. CB2 agonists demonstrate anti-inflammatory activity in T cells, B cells, macrophages, and monocytes. They have been identified in the gastrointestinal tract, indicating a possible therapeutic intervention in conditions such as inflammatory bowel disease and Crohn's disease.

Anti-Plaque Effect

• CB2 receptors are not expressed on neurons, but they are highly expressed on microglia, also known as the immune cells of the brain. Research points to the beneficial effects of CB2 activation during the inflammatory phase of acute brain injury. Additional research suggests a specific role for CB2 agonists in stimulating removal of neurotoxic β-amyloid plaque from brains of Alzheimer's patients.

Peripheral Nervous System

• Other research into the neurological effects of CB2 agonists has focused on their role in the peripheral nervous system. CB2-specific agonists have demonstrated significant control of inflammation and neuropathic pain. Other studies indicate a role for CB2 agonists in the proliferation of neural stem cells.