Does neosporin ointment work on staph infection?

While Neosporin ointment can help prevent infection in minor cuts and scrapes, it is not typically effective in treating staph infections. Staph infections are caused by bacteria called Staphylococcus aureus, and they often require antibiotic treatment to clear the infection. Neosporin ointment contains the antibiotics polymyxin B and neomycin, but these antibiotics are not effective against staph bacteria.