What is leukodepletion?

Leukodepletion is a process that removes white blood cells from blood components, such as platelets and red blood cells, to reduce the risk of transfusion-related immune reactions.

White blood cells can carry antigens that can trigger an immune response in the recipient of the blood component. This response can range from mild to severe and can include:

* Fever

* Chills

* Hives

* Difficulty breathing

* Anaphylaxis

Leukodepletion is performed by filtering the blood component through a filter that traps the white blood cells. The filtered blood component is then transfused to the patient.

Leukodepletion is required for all blood components that are transfused to patients who are at risk of transfusion-related immune reactions, such as:

* Patients who have had a previous transfusion reaction

* Patients who have a history of autoimmune disorders

* Patients who are immunosuppressed

Leukodepletion is also recommended for all blood components that are transfused to neonates, as they are at increased risk of developing transfusion-related immune reactions.