What is Reglan induced Tardive dyskinesia?

Tardive dyskinesia (TD) is an abnormal involuntary movement syndrome that can develop after long-term use of dopamine receptor antagonist (DRA) medications, such as Reglan (metoclopramide). It is characterized by repetitive, involuntary movements of the face, mouth, and extremities, such as grimacing, lip smacking, tongue protrusion, and chorea (involuntary, dance-like movements).

Reglan-induced TD refers specifically to TD that develops as a result of taking Reglan. Reglan is a medication used to treat gastroesophageal reflux disease (GERD) and diabetic gastroparesis (a condition that affects the stomach's ability to empty). It is a dopamine receptor antagonist, which means it blocks the action of dopamine in the brain. Prolonged use of DRAs, including Reglan, can alter dopamine signaling and lead to TD in some individuals.

TD can range from mild to severe and can significantly affect a person's quality of life. It can cause social embarrassment, functional impairment, and distress. Treatment for TD may involve reducing or discontinuing the offending medication, trying other medications or treatments to manage the movement disorder, and supportive measures to help manage symptoms and improve function.

It's important for healthcare providers to carefully monitor patients taking Reglan or other DRAs for TD and to balance the benefits of the medication against the potential risk of developing this movement disorder.