What is the relationship between malaria and mosquitoes?

Mosquitoes are the primary vectors of malaria, responsible for transmitting the parasite Plasmodium between infected individuals and susceptible hosts. When an uninfected mosquito bites an infected person, it ingests a blood meal containing Plasmodium gametocytes. Inside the mosquito's gut, these gametocytes mature and reproduce, forming male and female gametes that fuse to create zygotes. The zygotes develop into ookinetes, which travel to the mosquito's salivary glands. When the mosquito bites another person, these sporozoites are injected into the bloodstream, initiating a new malaria infection.

Therefore, the relationship between malaria and mosquitoes is one of a vector-borne disease transmission, where the mosquito acts as an intermediate host for the parasite, facilitating its spread between human hosts.