What is topical chemotherapy?

Topical chemotherapy involves the application of medications directly to the affected area of the skin to treat skin cancers. These medications can be in various forms, including creams, gels, ointments, or lotions. Topical chemotherapy can be used as a primary treatment for certain skin cancers or in conjunction with other therapies. It is considered less invasive and generally better tolerated than systemic therapies, which affect the entire body.

Some commonly used topical chemotherapy agents include:

5-fluorouracil (5-FU): This medication is frequently used to treat actinic keratosis, basal cell carcinoma, and superficial squamous cell carcinoma.

Imiquimod: Imiquimod acts as an immune response modifier, stimulating the body's immune system to recognize and attack cancerous cells. It is primarily used to treat certain types of superficial skin cancer, especially basal cell carcinoma.

Ingenol mebutate: This topical medication is utilized for the treatment of actinic keratosis.

Tirbanibulin: Tirbanibulin is a relatively new topical chemotherapy agent approved for treating basal cell carcinoma.

The specific topical chemotherapy agent and treatment regimen are determined by the type and stage of skin cancer, as well as the individual's overall health and preferences. Regular monitoring and follow-up appointments with a healthcare provider are essential to assess the effectiveness of the topical chemotherapy and identify any potential side effects.