What Is Mucin-Based Colon Cancer?

Mucin is a protein and the main component of the mucous layer protecting your intestines. According to research published in the Israel Medical Association Journal in 2000 by Dr. Yaron Niv, "several lines of evidence point towards a biological role of mucin in colorectal cancer."

Mucin's Role

• Research published in the British Medical Journal in October 2000 indicates that mucin's primary role is as a protective barrier against infection. Different genes make up mucin proteins, with MUC2 and MUC3 found in the colon. These mucin proteins have been found in cancer tissue but in altered form.

Causes

• MedicineNet.com lists high-fat diets, polyps, and genetics as possible causes of mucin-based colon cancer.

Symptoms

• Colon cancer symptoms include rectal bleeding or blood in the stool; persistent abdominal discomfort or cramps; fatigue; constipation or diarrhea lasting longer than two weeks; and unexplained weight loss.

Prognosis

• According to Niv, mucin-based colon cancer penetrates non-cancerous tissue more quickly, with more involvement of the lymph nodes. It metastasizes, or spreads, rapidly, with the survival rate being around five years.

Prevention

• The Mayo Clinic recommends colon cancer screening starting at age 50; African-Americans should start at 45. Minimize alcohol consumption, give up smoking and eat a diet high in vegetables and whole-grain foods to reduce your risk of colon cancer.