Would a karyotype reveal the presence of sickle-cell disease why or not?

No, a karyotype would not reveal the presence of sickle-cell disease.

Karyotyping is a laboratory technique used to analyze the chromosomal makeup of cells. It involves staining and banding the chromosomes in order to view their size, shape, and number. Sickle cell disease, on the other hand, is a genetic disorder caused by a mutation in the hemoglobin beta-globin gene (HBB) on chromosome 11. It is not detectable through karyotyping because it does not affect the structure or number of chromosomes. Karyotypes are instead useful for identifying chromosomal abnormalities such as aneuploidies, deletions, duplications, translocations, and inversions.