Do red blood cells that cause sickle anaemia have cell organelles?

Red blood cells, including those affected by sickle anaemia, do not contain cell organelles. Unlike other cells in the body, mature red blood cells lack a nucleus and other typical organelles such as mitochondria, endoplasmic reticulum, and lysosomes. They are essentially bags filled with haemoglobin, the protein responsible for carrying oxygen throughout the body. The absence of organelles allows these cells to be highly flexible and efficient in transporting oxygen through narrow blood vessels.