Can you grow a human liver from portion of liver?

Yes, it is indeed possible to grow a human liver from a portion of liver through a process known as liver regeneration. This remarkable ability of the liver to regenerate is a vital mechanism that allows it to repair and restore itself after injury or partial removal.

When a portion of the liver is removed, the remaining liver tissue responds by initiating a cascade of cellular events that lead to the growth and regeneration of new liver cells. This process involves several key steps:

1. Hepatocyte Proliferation: The existing hepatocytes (liver cells) in the remaining liver tissue undergo rapid proliferation, dividing and multiplying to increase their numbers.

2. Bile Duct Proliferation: The bile ducts within the liver also undergo proliferation, forming new bile ductules that help transport bile from the regenerating liver tissue.

3. Formation of Liver Lobules: As new hepatocytes and bile ducts form, they organize themselves into structures called liver lobules, which are the basic functional units of the liver.

4. Vascularization: The regenerating liver tissue develops new blood vessels to support the increased metabolic demands of the growing liver cells.

5. Functional Restoration: The newly formed liver cells mature and acquire the specialized functions of hepatocytes, such as synthesizing proteins, detoxifying substances, and producing bile.

This entire process of liver regeneration typically takes place over several weeks to months, and it allows the liver to restore its original size, structure, and function. It's important to note that liver regeneration is most effective when a sufficient portion of the liver remains after the partial removal or injury. In some cases, if a large portion of the liver is lost or damaged, liver transplantation may be necessary.