Do lymphocytes spend little time in the blood?

Lymphocytes do not spend little time in the blood. In fact, they circulate continuously between the blood and the lymphatic system, which is a network of vessels and nodes that helps the body fight infection. Lymphocytes are a type of white blood cell that helps the body fight infection. They are produced in the bone marrow and mature in the thymus gland. Once mature, lymphocytes circulate in the blood and lymphatic system, where they can come into contact with foreign substances, such as bacteria and viruses. When lymphocytes encounter a foreign substance, they can bind to it and destroy it.