What Is Lipohypertrophy?

Lipohypertrophy is a medical term used to describe an abnormal increase in the size of fat cells in a particular area of the body. It is commonly associated with long-term administration of insulin injections in individuals with diabetes, particularly type 1 diabetes, where insulin is required to manage blood sugar levels.

When insulin is injected into the same spot repeatedly over time, it can lead to the accumulation of fat cells in that particular area. This buildup forms a raised, firm lump or bump under the skin, called a lipohypertrophy nodule. Lipohypertrophy can occur anywhere on the body where insulin is injected, including the abdomen, thighs, arms, and buttocks.

Although lipohypertrophy is usually not painful or harmful, it can affect the absorption and effectiveness of insulin, leading to fluctuations in blood sugar levels. It can also become uncomfortable and interfere with daily activities, such as wearing certain clothing or sitting comfortably.

To prevent lipohypertrophy, it is essential for individuals with diabetes to rotate injection sites and avoid reusing the same spot repeatedly. Other preventive measures include proper injection techniques, such as inserting the needle at a 45-degree angle and pinching the skin before injection. If lipohypertrophy does develop, it is advisable to consult a healthcare provider for appropriate management.