What is the meaning for complex endometrial hyperplasia with adelphia?

Complex endometrial hyperplasia with adenomatous hyperplasia (CEH) is a condition in which the tissue lining the uterus (the endometrium) grows too thick and abnormal, increasing the risk of developing endometrial cancer.

Features of complex endometrial hyperplasia with adenomatous hyperplasia include:

- The presence of multiple glands or glandular complexes without cellular stratification.

- The growth of the glands into a maze-like pattern.

- The presence of endometrial stroma that is cellular and appears to be proliferative.

- The glands may be dilated, lined by hyperchromatic cells, and may have a pseudostratified appearance.

CEH is considered a precancerous condition, meaning it has the potential to develop into endometrial cancer. However, not all cases of CEH will progress to cancer. The risk of cancer development depends on several factors, including the degree of atypia (abnormality) in the endometrial cells and the presence of other risk factors for endometrial cancer, such as obesity, diabetes, and certain genetic mutations.

Treatment for complex endometrial hyperplasia with adenomatous hyperplasia typically involves removing the entire uterus (a hysterectomy) to eliminate the risk of endometrial cancer. In some cases, hormonal therapy may be used as an alternative to hysterectomy, especially for women who want to preserve their fertility.