Does the outermost layer of skin have nucleus?

The outermost layer of the skin, known as the epidermis, does not contain cells with nuclei. It consists primarily of dead skin cells, called keratinocytes, that have flattened and lost their nuclei as they moved to the outermost layer of the skin. These dead skin cells provide a protective barrier against environmental elements and serve as a waterproof layer, preventing water loss from the body. The living layers of the skin, which contain cells with nuclei, are located deeper within the epidermis and are responsible for various functions such as cell division, pigment production, and sensation.