Can allergy shots cause hives or itching?

Yes, it is possible for allergy shots to cause hives or itching as a side effect. These reactions usually occur shortly after the shot is given. The hives or itching typically resolve within a few hours, but in some cases may persist for longer. Other side effects of allergy shots can include swelling, redness, and pain at the injection site, as well as headaches, muscle aches, and fatigue. These side effects typically diminish as treatment continues. It is important to discuss any side effects with the doctor before continuing treatment.