How Biologics Treat Psoriatic Arthritis

Biologics are a type of medication used to treat psoriatic arthritis (PsA). They are a newer class of drugs that target specific parts of the immune system involved in the inflammation and damage caused by PsA.

Biologics work by blocking the action of certain proteins or molecules in the body that play a role in inflammation. By doing so, they can help to reduce the symptoms of PsA, such as joint pain, swelling, and stiffness.

There are several different types of biologics that are used to treat PsA. Some of the most common include:

* Tumor necrosis factor (TNF) inhibitors: These drugs block the action of TNF, a protein that is involved in inflammation. TNF inhibitors are effective in treating the symptoms of PsA and can also slow down the progression of the disease. Some examples of TNF inhibitors include infliximab (Remicade), etanercept (Enbrel), adalimumab (Humira), certolizumab pegol (Cimzia), and golimumab (Simponi).

* Interleukin (IL) inhibitors: These drugs block the action of IL-12 and IL-23, two proteins that are involved in inflammation. IL inhibitors are effective in treating the symptoms of PsA and can also slow down the progression of the disease. Some examples of IL inhibitors include ustekinumab (Stelara), secukinumab (Cosentyx), and ixekizumab (Taltz).

* T-cell inhibitors: These drugs block the action of T cells, a type of white blood cell that is involved in the immune response. T-cell inhibitors are effective in treating the symptoms of PsA and can also slow down the progression of the disease. Some examples of T-cell inhibitors include abatacept (Orencia) and tofacitinib (Xeljanz).

Biologics are generally well-tolerated, but they can cause side effects. Some of the most common side effects include injection site reactions, headaches, nausea, and diarrhea. Biologics can also increase the risk of infection, so it is important to take precautions to avoid getting sick.

Biologics are a powerful treatment option for PsA. They can help to reduce the symptoms of the disease and slow down its progression. If you are considering biologic therapy for PsA, talk to your doctor about the risks and benefits of this treatment option.