How Nucala Helps With Severe Asthma and What to Expect

## How Nucala Helps with Severe Asthma

Nucala (mepolizumab) is a biologic medication used to treat severe asthma in people aged 12 and older. It is a humanized monoclonal antibody that targets interleukin-5 (IL-5), a cytokine that plays a role in the inflammatory process of asthma. By binding to IL-5, Nucala blocks its interaction with its receptor, preventing the activation of eosinophils, a type of white blood cell that is involved in allergic reactions.

Nucala is administered as a subcutaneous injection every 4 weeks. It is typically used in combination with other asthma medications, such as inhaled corticosteroids and long-acting beta-agonists.

What to Expect When Taking Nucala

Nucala is generally well-tolerated. The most common side effects include:

* Injection site reactions (pain, redness, swelling)

* Headache

* Fatigue

* Nausea

* Diarrhea

These side effects are usually mild and go away after a few weeks.

Nucala may also cause serious side effects, such as:

* Serious allergic reactions (hives, swelling of the face, throat, or tongue, difficulty breathing)

* Serious infections (pneumonia, tuberculosis)

* Cancer (such as lung cancer or skin cancer)

If you experience any of these side effects, stop taking Nucala and call your doctor immediately.

How to Take Nucala

Nucala is administered as a subcutaneous injection. The injection is given into the upper arm, thigh, or abdomen.

Your doctor will show you how to give the injection yourself. If you have any questions about how to give the injection, be sure to ask your doctor or pharmacist.

Storage

Nucala should be stored in the refrigerator at 36°F to 46°F (2°C to 8°C). Do not freeze.

Cost

The cost of Nucala varies depending on the dose and the frequency of administration. The average cost of a monthly dose of Nucala is around $1,500.

Conclusion

Nucala is an effective treatment for severe asthma. It is generally well-tolerated, with most side effects being mild and temporary. Nucala is expensive, but it can be a lifesaving medication for people with severe asthma.