Unmatched blood group will cause problem?

Yes, unmatched blood group can cause problems during blood transfusion. When blood is transfused from one person to another, the recipient's immune system checks for any foreign antigens on the donor's red blood cells. If the recipient's immune system detects incompatible antigens, it produces antibodies against those antigens, leading to a reaction known as hemolytic transfusion reaction. This reaction can cause the destruction of transfused red blood cells, leading to serious health complications such as:

1. Hemolysis: The recipient's antibodies attack and destroy the donor's red blood cells, resulting in their rupture and release of hemoglobin into the bloodstream. This can lead to anemia, kidney failure, and other serious complications.

2. Fever and Chills: Transfusion of incompatible blood can cause the recipient to experience fever, chills, and other signs of an immune response.

3. Allergic Reactions: Some individuals may have allergic reactions to specific components present in the donor's blood, such as plasma proteins, which can lead to symptoms like hives, itching, and difficulty breathing.

4. Graft-versus-Host Disease (GVHD): In rare cases, transfusion of incompatible blood can lead to GVHD, a condition where the donor's immune cells attack the recipient's tissues, causing damage to various organs and systems.

5. Organ Damage: Severe hemolytic transfusion reactions can lead to organ damage, including kidney failure, liver damage, and brain damage.

6. Risk of Infection: Incompatible blood transfusions can also increase the risk of transmitting infections from the donor to the recipient.

7. Death: In severe cases, unmatched blood transfusions can lead to life-threatening complications and even death.

Therefore, it is crucial to ensure proper blood typing and cross-matching procedures are followed before performing blood transfusions to avoid these potentially life-threatening complications.