The genetic disease in which hemoglobin changes shape and the red blood cells become stiff sticky is called?

The genetic disease in which hemoglobin changes shape and the red blood cells become stiff and sticky is called sickle cell anemia. This condition is caused by a mutation in the beta-globin gene, which leads to the production of abnormal hemoglobin (hemoglobin S). Hemoglobin S is less soluble than normal hemoglobin, and it can cause the red blood cells to become sickle-shaped when they are deprived of oxygen. These sickle-shaped cells can get stuck in small blood vessels, which can lead to pain, tissue damage, and organ failure.