What effect will NRBCs in the peripheral blood have on cbc report?

Nucleated red blood cells (NRBCs) are immature red blood cells that are normally found in the bone marrow. In healthy adults, NRBCs are not normally present in the peripheral blood. However, in some conditions, such as anemia, leukemia, and myelodysplasia, NRBCs may be released into the peripheral blood.

The presence of NRBCs in the peripheral blood can affect the results of a complete blood count (CBC). NRBCs can be counted as either red blood cells or white blood cells, depending on their size and appearance. This can lead to an falsely high or falsely low red blood cell count or white blood cell count.

In addition, NRBCs can interfere with the measurement of other parameters in a CBC, such as the hematocrit and the hemoglobin concentration. This is because NRBCs are larger and contain less hemoglobin than mature red blood cells. As a result, the presence of NRBCs in the peripheral blood can lead to an falsely high hematocrit and an falsely low hemoglobin concentration.

The presence of NRBCs in the peripheral blood is a sign of an underlying medical condition. If NRBCs are found in your peripheral blood, your doctor will investigate to determine the cause and recommend appropriate treatment.