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What Is Fibrin Sealant?

Fibrin sealants, also known as fibrin glues, are an adhesive used in surgery. The sealant is derived from blood products of humans and animals.

  1. History

    • Fibrin sealant was first created during World War II to help stop hemorrhaging from wounds acquired during battle. Since 1980, fibrin glues have been in use in Western Europe and Japan, but were only approved for use in the United States in 1998. The delay was due to worries about virus contamination in blood products.

    Ingredients

    • The two main ingredients of fibrin sealants are the enzyme, thrombin and the protein fibrinogen. The source of these ingredients is either from humans or from cows. In addition, fibrin sealants contain human blood factor XIII which strengthens blood clots and aprotinin which stops enzymes that are involved in breaking down blood clots.

    Effectiveness

    • Fibrin sealants help to shorten surgery time as well as minimize the amount of blood lost during a surgical procedure. The sealant also reduces the extent of scar tissue formation at incision sites.

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