Differences Between Boniva & Fosamax

Boniva and Fosamax are the two leading prescription medications that prevent and treat osteoporosis, or bone loss. Both Fosamax and Boniva are in a class of drugs called bisphosphonates, which are commonly prescribed to build bone density and mass. While the drugs are used to treat the same condition, they also bear a few differences.

Active Ingredients

• While both drugs are bisphosphonates, Boniva's generic name is ibandronic acid or ibandronate sodium. It is a potent nitrogen-containing bisphosphonate specifically designed as a monthly bone-loss treatment for postmenopausal women, and not recommended for men. Fosamax, on the other hand, is an alendronic acid or alendronate sodium, and can be taken by both men and women. It also can treat other bone diseases such as Paget's disease.

Possible Side Effects

• While both drugs can have common side effects like heartburn, nausea, muscle pains, flu symptoms and stomach problems, a more severe side effect has been reported for Fosamax users only: There were a reported 23 cases of esophageal cancer between October 1995 and May 2008, with doctors finding a possible link among Fosamax, the cancer and the medical history of the particular patients.

Time on the Market

• Fosamax was the first FDA-approved drug to treat osteoporosis and has been on the market since 1995. Boniva made its market debut in 2005. Because of its 10-year head start, there have been more reports on the long-term side effects as well as the benefits of Fosamax.

Intake

• Fosamax is a weekly medication whereas Boniva can be taken once a month orally, or given as an injection every three months. Those taking Boniva or Fosamax orally must take it first thing in the morning on an empty stomach, remaining upright for the entire time and for a short while afterward.