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What Is Trigosamine?

PatentHEALTH LLC markets Trigosamine as a dietary supplement for relieving pain due to the deterioration of joints. The company also claims that Trigosamine builds and maintains cartilage. Using Trigosamine for ailments has some scientific support, though the evidence is not conclusive.

  1. Ingredients

    • Trigosamine contains 13 mg of hyaluronate, 1,300 mg of chondroitin and 1,500 mg of glucosamine.

    Evidence for Effectiveness

    • No published research supports the safety and efficacy of Trigosamine. However, use of each of the individual active ingredients in the supplement has been shown to help relieve some of the pain and joint damage that accompanies osteoarthritis. In prescription strength, hyaluronate is injected into arthritic knees to relieve pain and stimulate cartilage growth. A meta-analysis reported in the June 2009 issue of the journal "Modern Rheumatology" supports this use, but the scientific literature database maintained by the National Library of Medicine maintains no comparable evidence for hyaluronate taken orally.

      Evidence does exist for the efficacy of oral chondroitin and glucosamine, however. Reporting on their analysis of several other studies of glucosamine or chondroitin supplements for treating osteoarthritis, Y.H. Lee and colleagues wrote in an article in "Rheumatology International" that taking either of the supplements for as long as three years significantly slowed joint damage.

    Dosing

    • PatentHEALTH recommends patients take a single Trigosamine caplet each day.

    Warnings

    • People with shellfish allergies or asthma cannot take Trigosamine as the glucosamine used in the supplement comes from shells. Also, chondroitin may trigger bronchospasms in people with asthma. Rarely, individuals taking chondroitin have reported headache, rash, photosensitivity, hair loss, breathing difficulties, elevated blood pressure, foot and eyelid swelling and upset stomach.

    Potential Drug Interactions

    • Glucosamine can increase the strength of non-steroidal anti-inflammatory drugs and increase or decrease patients' needs for oral anti-diabetic medications. Neither hyaluronate nor chondroitin appears to affect the actions of other medications in the body.

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