Can neurotransmitters cross the synaptic cleft?

Yes, neurotransmitters cross the synaptic cleft to transmit signals between neurons. When an electrical signal reaches the axon terminal, it triggers the release of neurotransmitters into the synaptic cleft. These neurotransmitters diffuse across the synaptic cleft and bind to specific receptors on the postsynaptic neuron, causing a change in the electrical potential of that neuron. This change in electrical potential can either excite or inhibit the postsynaptic neuron, depending on the type of neurotransmitter and receptor involved.