When were central nervous depressants made?

Central nervous depressants have been utilized throughout human history, with traces of opium use found as early as 5800-5600 B.C. in an Iranian Neolithic village. These substances often occurred naturally, derived from plants such as the poppy flower or mushrooms. However, the modern scientific production of depressants gained momentum primarily during the 19th and 20th centuries when researchers began synthesizing chemicals and medications that targeted their effects on the central nervous system.