Action-Myoclonus Renal Failure Syndrome

Myoclonus is, according the National Institute of Neurological Disorders and Stroke, a physical event in which a muscle contracts and then relaxes. Action-myoclonus Renal Failure Syndrome (AMRF syndrome) is an exceedingly rare condition with both physiological and neurological effects.

Onset

• The neurology journal "Brain" reports that onset of the condition generally begins in the 20s or 30s. However, renal (kidney) problems generally begin to manifest prior to full onset of AMRF syndrome.

Causes

• The causes of the condition remain unclear. There is evidence to suggest that the condition is genetic in basis and inherited through recessive genes.

Symptoms

• The symptoms of AMRF syndrome include tremors, ataxia and seizures. "Brain" notes that renal failure will manifest as the condition progresses but that cognitive function is not affected by the condition.

Treatments

• The primary treatment options are dialysis or kidney transplant to address the renal failure. Prescription medications can be used to reduce the occurrence of tremors and seizures.

Long Term

• If the renal failure goes undiagnosed, the condition is typically fatal. If the renal failure is appropriately treated and the other neurological features are controlled, it can prolong the life of the patient, but the duration varies from case to case.