Cortisol as a Treatment for ALS

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, attacks the motor neurons in the body. It usually attacks people ages 40 to 70, and affects at least 30,000 Americans at a time. The disease is reportedly caused by the mutation of the SOD1 gene.

What is ALS?

• Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease, which attacks and slowly kills certain nerve cells (motor neurons) in the brain and spinal cord. These nerve cells control muscles that cause the movement of body parts. As the ALS progresses it eventually leads to disability, and makes it very difficult for the individual to walk, speak, eat, swallow and breathe, which eventually leads to death.

Symptoms of ALS

• The disease begins with the most common symptoms of weakness in the hand, foot, arm or leg, and is common in more than half of the cases. Other symptoms in the early stages include speech, swallowing and difficulty walking.

Diagnosis

• The diagnosis of ALS is based on extensive scrutiny in the patient's medical history, physical examination of the nervous system, and testing of the nerves and muscles.

Treatment

• There is no cure for ALS. Treatment such as Cortisol can help delay progression of the disease by strengthening the muscles, increasing the individual's independence, managing symptoms and giving emotional support

Advantages of Cortisol

• Cortisol is a steroid hormone formed in the adrenal glands, located close to the kidneys. It is released by the glands during periods of stress, and is called a "stress hormone." It has a major role in the functioning of almost all body parts. Cortisol is made of cholesterol, and affects many physiologic systems, such as immune function, the regulation of glucose counter, vascular tone, and metabolism of the bone. Cortisol transforms proteins into energy, releases glycogen and counteracts inflammation.

Disadvantages

• However, if the levels are excessively high, it eventually breaks down the healthy muscles and bones, and slows the healing process and the regeneration of normal cells. It also joins biochemicals required in the production of vital hormones, impairing the digestive process. It affects the metabolic and mental process, interfering with healthy endocrine function, and weakens the immune system.