Is the left ventricle thicker than right because pumps blood against a greater resistance?

Yes, the left ventricle is thicker than the right ventricle because it pumps blood against a greater resistance.

Cardiac muscle mass: The left ventricle has a greater mass compared to the right ventricle due to the increased workload and pressure it must generate.

Anatomical differences: The left ventricle has a thicker myocardial wall compared to the right ventricle. This increased thickness allows the left ventricle to generate higher pressures necessary for systemic circulation.

Increased pressure: The left ventricle pumps blood into the systemic circulation, which includes the entire body. The systemic circulation has a higher resistance compared to the pulmonary circulation, which the right ventricle pumps into. This increased resistance necessitates the left ventricle's greater thickness and strength.

Valves: The left ventricle is connected to the aortic valve, which must withstand higher pressures compared to the pulmonary valve connected to the right ventricle. The thicker left ventricle helps maintain pressure and prevent backflow during systole.

Functional demands: The left ventricle must generate a higher ejection fraction to propel oxygenated blood throughout the body. This requires more powerful contractions, necessitating a thicker muscle structure.