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Tussionex Pennkinetic Suspension MPI Side Effects

Tussionex Pennkinetic suspension, most commonly called Tussionex, is a syrup available by prescription for the treatment of cough due to allergy, cold or flu. Tussionex contains hydrocodone, a narcotic, and chlorpheniramine, an antihistamine, suspended via a specialized pharmaceutical process within a liquid matrix. This specialized formulation allows Tussionex to provide long-acting effects against cough and allergy symptoms.

  1. Side Effects

    • Drowsiness and dizziness are the most common side effects of Tussionex suspension. Patients should not operate machinery or drive while taking Tussionex. The sedative effects of Tussionex may be enhanced by alcohol, other narcotics, benzodiazepines, such as Valium or Xanax, certain seizure drugs and some anti-depressant agents. Before mixing Tussionex with other medications, patients should consult a physician or pharmacist.

      As with all opiate narcotics, Tussionex may cause a decrease in the frequency and depth of respiration. Additional narcotics, benzodiazepines, barbiturates, or alcohol can enhance these effects. Tussionex should be used judiciously in children and the elderly, as these populations may be especially sensitive to its effects on breathing.

    Hypersensitivity

    • Patients experiencing rash, breathing or swallowing difficulty, itching or swelling should seek prompt medical attention. Non-allergic itching may occur with hydrocodone use, but should still be reported to a physician. Those with a known sensitivity to hydrocodone, morphine, codeine and other opiates, chlorpheniramine or other antihistamines should not take Tussionex syrup.

    Dosage and Dispensing

    • Traditional cough suppressants require dosing every four to six hours, up to six times daily but the extended-release mechanism of Tussionex allows it to be taken twice a day. Each teaspoon of Tussionex contains 10mg hydrocodone and 8mg chlorpheniramine. The usual adult dose is 5ml, or one teaspoonful every twelve hours. Adult patients should not exceed 10ml in 24 hours. Because it is a suspension, Tussionex should be shaken well prior to use to evenly distribute the active ingredients through the liquid.

    Dependence and Abuse Potential

    • Temporary use of anti-cough preparations containing opiates is not likely to result in dependence. According to the US Drug Enforcement Agency (DEA), misuse of narcotic medications such as hydrocodone account for 75% of all prescription drug abuse. The DEA also lists hydrocodone as the number one target of abuse among controlled medications in the US.

      Because of its yellowish color and pleasant taste, Tussionex is referred to in street culture as "Liquid Gold." Patients prescribed Tussionex should take care to keep it secured.

    Legalities

    • Tussionex suspension is classified as a Schedule III controlled substance under federal law and is regulated by federal and state statutes. These laws may impart quantity, refill and duration of use limits on Tussionex. Federal law prohibits the transfer of Tussionex to anyone for whom it was not prescribed.

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