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Role of L-Tryptophan in Serotonin

L-tryptophan, also known just as tryptophan, is an essential amino acid that is needed for normal development in infants. It is also required for nitrogen balance in adults. L-tryptophan is also involved in the synthesis of serotonin.

  1. Sources of Tryptophan

    • Tryptophan is present in turkey meat and is often blamed for causing tiredness after traditional Thanksgiving meals. Tryptophan is also found in bananas, milk, cheese and bread.

    Serotonin Precursor

    • Serotonin is a chemical that plays a role in transmitting signals between nerve cells. It is created in the brain and is found in the digestive tract, blood platelets as well as in the brain itself. Serotonin has been linked to elevating moods and is believed to facilitate sleep. Serotonin levels in the central nervous system play a role in depression, appetite and the sensation of pain. Due to its role as a precursor to serotonin, tryptophan is used as a sleep aid and anti-depressant.

    Food and Tryptophan

    • Food affects the production of serotonin and tryptophan plays a role in this cycle. After eating a meal rich in carbohydrates, insulin is produced and has the effect of lowering the levels of most amino acids in the blood. However, tryptophan is not affected by insulin in the same way and as a result it now enters the brain via the blood-brain barrier at an increased rate. The result is an increase in serotonin production.

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