How do I Switch From Wellbutrin to Effexor?

Switching antidepressants is a delicate situation in that every change in dose may cause side effects. The type of antidepressant, medical history and other medications are all deciding factors the doctor will use to determine whether switching from Wellutrin to Effexor is a safe decision for you. Both Wellbutrin and Effexor manipulate norepinephrine, which is a hormone and neurotransmitter. Wellbutrin is a norepinephrine-dopamine reuptake inhibitor (NDRI), and Effexor is a seratonin-norepinephrine reuptake inhibitor (SNRI), which are separate classes of antidepressants.

Instructions

• 1

  Ask your doctor about Effexor. Explain what issues you have with continuing the use of Wellbutrin and why you would like to try Effexor. The doctor will ask questions about the side effects you experienced on Wellbutrin. It is important to be honest when she inquires about any additional medications you are taking.

• 2

  Follow the doctor's directions for stopping the use of Wellbutrin. The doctor will prescribe a method for slowly stepping down the dose and eventually stopping while slowly introducing Effexor. Depending upon how high your current dose of Wellbutrin is, this process could take months because Effexor cannot be introduced until the Wellbutrin is lowered to a dose that will not react adversely.

• 3

  Take the start-up packet for Effexor as directed. It can take weeks to feel the effects of Effexor, so it is important just to continue taking it. This method prevents discontinuation syndrome in the process of switching medications. "Discontinuation syndrome" is the term used for withdrawal symptoms after discontinuing drugs not shown to be addictive. The doctor will step your dose up gradually and check on your mental health to ensure your body is handling the switch.

• 4

  Monitor yourself for side effects such as extreme mood swings, changes in appetite, fatigue, drowsiness, insomnia, thoughts of suicide, dizziness, nausea, anxiety, sweating, upset stomach, yawning, weight loss, constipation, blurred vision or changes in taste. Be sure to report any side effects and severe changes to your doctor. This may require the help of a loved one who sees you on a daily basis and might notice additional mental health issues that you cannot.