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Most Effective Treatments for Major Depressive Disorder

Major depressive disorder is diagnosed when a patient has symptoms of depression for two weeks or longer. Symptoms of depression may include feeling hopeless, pessimistic and worthiness. Researchers are still learning more about the causes of major depressive disorder, however, a chemical imbalance in the brain may play a role. Fortunately, there are many treatments that can effectively treat major depression disorder.

  1. Medications

    • According to the Mayo Clinic, anti-depressants are usually an effective treatment for major depressive disorder. Typically, doctors will start patients on a selective serotonin reuptake inhibitor, also called "SSRIs." Medications in this class include Paxil, Zoloft, Celexa and Lexapro.

      SSRIs usually have less side effects then tricyclici antidepressants, also known as TCAs. This class of drug has been around longer then SSRIs but has potential for more side effects. Doctors typically try these medications if the patient isn't responding to SSRIs.

      Doctors may also prescribe two or more antidepressants to provide a better result, according to the Mayo Clinic. This strategy is called "augmentation" and is usually reserved for patients who aren't responding well to other treatments.

    Medication Warnings

    • According to the Mayo Clinic, antidepressants are usually safe. However, some patients have side effects, such as suicidal thoughts, liver failure or white blood cell count changes. Most of these side effects occur when starting a medication or changing the dosage. Family members should monitor their loved ones carefully and report changes to the physician right away.

    Psychotherapy Treatment

    • Psychotherapy is an important part of treating major depressive disorder. During this therapy, the patient will discuss their condition and how it's affecting their life. The psychotherapist will help the patient better understand the condition and implement strategies for changing unhealthy behaviors or patterns.

      According to the Mayo Clinic, psychotherapy can help restore a sense of happiness to the patient's life. It can also minimize feelings such as anger and feeling hopeless.

    Electroconvulsive Therapy (ECT)

    • ECT is a treatment where electrical currents are sent to the brain. These currents trigger a seizure in the brain that can provide quick relief from depression symptoms, according to the Mayo Clinic. The procedure appears to target the neurotransmitters in the patient's brain.

      This treatment is typically used on patients who aren't responding well to other medications and have a history of suicidal risk. Older adults are also good candidates for ECT because they may not be able to take antidepressants if they have a heart condition.

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