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Information on St. John's Wort

St. John's wort is a natural remedy for depression and anxiety that is available over the counter. However, there are some potential risks associated with taking St. John's wort, which is derived from the plant Hypericum perforatum. The herb is also not recommended for treating cases of suicidal or psychotic depression.

  1. Scientific Studies

    • Numerous studies have shown that St. John's wort can be as effective as tricyclic prescription antidepressants in treating cases of mild to moderate depression, according to MedlinePlus. However, the validity of some of these studies has been disputed. The general medical consensus is that St. John's wort cannot help major depression and is not as effective as selective serotonin reuptake inhibitors (SSRI) prescription drugs such as Prozac.

    Drug Interactions

    • A major concern associated with St. John's wort is its potential interactions with prescription and over-the-counter drugs, according to MedlinePlus. The herb should not be taken with MAOIs used to treat high blood pressure, as it can dangerously elevate blood pressure. Combining St. John's wort with prescription antidepressants can cause serotonin syndrome, which can lead to serious medical problems such as coma. It can also create mania, which is a potentially dangerous elevated mood.

    Precautions

    • Some patients may be able to take St. John's wort with their prescription drugs but may want to be mindful of potential side effects, according to MedlinePlus. The herb can cause irregular bleeding in women taking birth control pills. In rare cases, those taking blood thinners can also experience exacerbated side effects.

    Possible Side Effects

    • Side effects are possible with St. John's wort even when taken by itself, according to MedlinePlus. Sensitivity to sunlight, skin reactions, upset stomach, nausea, headache, anxiety, dizziness, headache and dry mouth are all possible side effects. In addition, allergic reaction is rare but can happen, and is characterized by hives, itching and difficulty breathing.

    Dosage and Cost

    • St. John's wort should be taken for periods of no longer than one to three months, according to MedlinePlus. Children under 18 can take the herb, and the usual recommended dosage is 150 to 1,800 mgs per day. Recommended adult dosages range from 900 to 1,800 mgs. As St. John's wort is an over-the-counter herbal remedy, virtually all health insurance plans expect patients to pay for such treatment. As of September 2009, St. John's wort cost about $5 for 40 450-mg capsules.

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