Lexapro Vs. Celexa

Celexa and Lexapro are two "cousin" drugs of the same class and are chemically similar, although opposites of each other. They are used to treat clinical depression. While very similar, the two drugs are not interchangeable. Understanding the differences between them can help a patient make an informed decision about which drug, if either, is right for him.

Similarities

• Celexa and Lexapro are both selective serotonin reuptake inhibitors (SSRIs). SSRIs work by making more serotonin, a neurotransmitter that plays a role in mood regulation, available within the brain, although scientists aren't certain exactly why it works in treating depression. Both drugs are manufactured by Forest Pharmaceuticals.

Differences

• Celexa was manufactured before Lexapro and is used to treat depression. Lexapro is chemically a mirror image of Celexa and can be used to treat both depression and anxiety. Celexa may work on anxiety, but its effectiveness in treating generalized anxiety disorder has not been established by studies. eMedTV also suggests that, based on depression research, Lexapro may be a more effective anti-depressant (eMedTV).

Side Effects

• All SSRIs have the same potential side effects, although patients may respond differently to one drug versus another because of the individual chemical makeup of the drug. These side effects include increased sweating, mild nausea, headache, dry mouth, decreased sex drive, weight gain, agitation, insomnia, drowsiness, and diarrhea. Most of these symptoms are not severe enough to cause patients to stop taking the medication. Serious side effects include however, thoughts of suicide and loss of appetite. (Drugs.com)

Withdrawal

• Although not technically addictive, Celexa and Lexapro can both cause withdrawal symptoms if the dosage is not properly tapered off. Even with tapering, there is a risk. Symptoms include dizziness, agitation, a tingling sensation in the extremities, dizziness, confusion, insomnia, anxiety, and headaches. If the symptoms become too overwhelming, the doctor may return the patient to the original dosages and wean more slowly. (eMedTV)

Considerations

• Celexa and Lexapro cannot be prescribed for those taking monoamine oxidase inhibitors (MAOIs), certain anti-psychotics. Those who've had allergic reactions to Celexa will not be able to take Lexapro and vice-versa. Patients should tell their doctor if they have liver or kidney disease, heart problems, or any other ongoing medical conditions. Serotonin syndrome, a very dangerous and potentially fatal syndrome, can occur when serotonin levels in the brain are too high. The herb St. Johns Wort and other supplements that increase serotonin levels should be avoided. Signs include extreme agitation, nausea and vomiting, hallucination, elevated blood pressure, seizures, and coma (Drugs.com, eMedTV).