Causes of Chronic Depression

Depression is a common mood disorder. It is a chronic mental illness and resurfaces even when a person is on antidepressants. Depressed people feel hopeless, lack energy and lose interest in life. Many factors cause depression.

Genetics

• Research indicates depression can run in some families. People are more prone to depression if there is a blood relative who suffers from the disorder.

Changing Levels of Neurotransmitters

• Neurotransmitters are brain chemicals that affect mood. When these chemical levels fluctuate, it can lead to depression. Researchers don't know how neurotransmitters affect mood, but when antidepressants are taken the symptoms are alleviated.

Physical Changes in Brain

• According to the Mayo Clinic, depression causes physical changes to the brain. High-tech images of the brain from MRI exams and CT scans reveal these changes, but researchers don't know how depression causes these changes.

Hormonal Changes

• Estrogen and testosterone may cause depression. More women than men suffer from depression. This may be due to the hormonal changes of menopause, menstruation and pregnancy.

Environmental Factors

• Personal events--a life-threatening illness, financial setback, divorce or death of a loved one--all can cause depression.