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Criteria for the Use of Amitiza

Amitiza is an oral medication that was approved by the U.S. Food and Drug Administration (FDA) in January of 2006 for the treatment of adult chronic constipation of unknown origin. Amitiza active ingredient is lubiprostone. It works on the chloride channels in the intestines, causing a secretion of fluid that helps to correct the problem and ease the symptoms. The drug's use requires meeting specific criteria.

  1. Chronic Constipation

    • Chronic constipation is found in both men and women, but is more common in women. Amitiza is prescribed after a diagnosis of adult chronic constipation with an unknown cause and fewer than three spontaneous bowel movements per week. This condition is usually accompanied by straining, abdominal bloating and abdominal discomfort. Amitiza is not considered until other treatments such as a bulk or osmotic laxative have been tried unsuccessfully.

    Irritable Bowel Syndrome with Constipation

    • In April 2008 Amitiza was approved by the FDA for the treatment of irritable bowel syndrome with constipation (IBS-C) in women older than 18. Amitiza can be prescribed after a diagnosis of IBS-C where there has been at least six months of pain or discomfort with straining or hard stools at least 25 percent of the time and less than three spontaneous bowel movements per week. If the woman is of child bearing age, there must be a negative pregnancy test and an understanding and ability to use contraception. Healthy diet and less evasive medications, such as bulk and osmotic laxatives, are considered before Amitiza. In IBS-C screening for colon cancer, hypothyroidism, pelvic floor abnormalities and spinal cord abnormalities need to be completed before taking this medication.

    Negative Indications

    • Amitiza cannot be taken by people with suspected bowel blockage or with kidney or liver disease. You have to be able to swallow a capsule. It is not for people with severe diarrhea or women trying to become pregnant, who are pregnant, or breast-feeding.

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