Where does the digestion of most macromolecules occur?

Most macromolecules are digested in the small intestine. The small intestine is a long, coiled tube that connects the stomach to the large intestine. It is lined with villi, which are small, finger-like projections that increase the surface area of the intestine and help to absorb nutrients. The small intestine also produces enzymes that break down macromolecules into smaller molecules that can be absorbed into the bloodstream.