Cures for Gadolinium Poisoning

Gadolinium is a a rare earth metal that is used to enhance an MRI (magnetic resonance image). It is injected intravenously, and once in the body it is absorbed by abnormal cells, growths and organs. On its own gadolinium is toxic to the human body, but when coated in a special chelating agent, it is safe to use. But when the chelating agent breaks down prematurely, or the kidneys are unable to excrete the gadolinium from the body, gadolinium poisoning can occur, which causes a condition known as nephrogenic systemic fibrosis (NSF).

Nephrogenic Systemic Fibrosis

• Nephrogenic systemic fibrosis occurs only in individuals with kidney disease, as a result of the impaired kidneys being unable to process and excrete the gadolinium that was injected prior to the MRI. Symptoms of the disease include swelling and tightening of the skin covering the extremities, skin thickening, muscle weakness and joint problems. As the disease progresses, the skin may undergo changes that include darkened patches, hardened areas and scarring. Burning, itching and sharp pains may also be prominent in areas of involvement.

Treatment & Curing of NSF

• As of December 2009, physicians are unable to find a treatment that consistently cures NSF. However, improving the renal function of kidney disease patients has shown success in slowing down the progress of NSF, or stopping it altogether. In many cases, improving renal function has successfully reversed the effects of nephrogenic systemic fibrosis over time.
  Kidney and liver transplants have been successful for three patients who took part in a study at Loma Linda University. It is thought that the introduction of better performing kidneys allowed the body to remove the build-up of gadolinium.
  Oral steroids such as prednisone are commonly prescribed to ease the symptoms of nephrogenic systemic fibrosis. If you have diabetes, use caution when taking oral steroids, as prednisone is known to increase the risks of hyperglycemia, a condition that raises blood glucose.
  The topical application of Dovonex combined with vascular compression stockings have shown success in improving localized areas of the body affected by gadolinium poisoning.
  Speak to your physician if you suspect you have gadolinium poisoning. The sooner you are evaluated and treatment is arranged, the more likely it is that the symptoms of NSF can be managed.