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Tylenol & Ibuprofen in Liver Disease

Tylenol and ibuprofen are over-the-counter medications that have the potential to increase the risk of hepatotoxicity (may be destructive to the liver). It is suggested that people who have been diagnosed with liver damage use these medications with caution.

  1. Liver Disease

    • Liver disease is a broad term used for the various diseases that affect the liver. The liver is responsible for converting nutrients, producing proteins and enzymes, balancing hormones and metabolizing certain medications.

    Significance

    • Tylenol (acetaminophen) and ibuprofen are both used to help relieve pain and reduce fevers. These medications are less toxic to the liver if used in moderation and according to recommended dosages.

    Considerations

    • For people diagnosed with liver disease, warnings apply to taking either acetaminophen or ibuprofen. The risk of liver damage is increased in individuals who take these medications and also consume alcoholic beverages.

    Drug-Induced Hepatitis

    • Hepatitis (inflammation of the liver) is a condition that can affect the liver when certain medications are taken. According to MedlinePlus, both acetaminophen and ibuprofen increase the risk of hepatitis if taken in quantities exceeding the recommended dosage (Resource 1).

    Facts

    • According to HCVAdvocate.org, acetaminophen-related liver toxicity is the leading cause of liver failure in the United States, accounting for more than 56,000 emergency room visits and 450 deaths yearly (Resource 2). The American Academy of Family Physicians suggests that patients diagnosed with chronic liver disease not use ibuprofen (Resource 3).

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