Instructions on How to Use Polyethylene Glycol 8000

Polyethylene glycol 8000 (methoxypolyethlene glycol) is a chemical used in the medical field to prevent colorectal cancer in animals called Carbowax. The chemical reaction is HOCH2CH2OH + n(CH2CH2O) ' HO(CH2CH2O)n+1H. Scientists would label this PEG 8000, referring to the weight of the polymer. This goes by the brand name Mircera for humans as a treatment for anemia associated with chronic renal failure.

Instructions

Dosage Instructions

• 1

  In humans, begin by getting blood levels simulated by using the Erythropoiesis-Stimulating Agent (ESA) for two weeks before starting the actual dosage of Mircera. This decreases oxygen to the kidneys. The stimulation occurs in the bone marrow in approximately seven stages. To help with this stimulation take vitamin B-12 and folic acid while maintaining a hemoglobin range between 10 and 12 g/dL. To achieve a favorable result, your doctor may prescribe erythropoietin as well.

• 2

  Watch your hemoglobin carefully. A 1g/dL difference signals a change in dosage. A change in dosage should only occur once a month. Every two weeks to one month you need a new injection. Inject an IV in your abdomen, arm or thigh. Whenever the hemoglobin level reaches 12, you need to reduce the dosage. Let 25 percent be your guide in increasing or decreasing the dosage amount.

• 3

  Continue treatments regularly to insure that your health improves. Reschedule missed appointments immediately and return to the prescribed dosage. You may need transfusions if your hemoglobin range changes too much.