How is duane syndrome inherited?

Duane syndrome is a rare congenital eye movement disorder that is usually inherited in an autosomal dominant pattern. This means that only one copy of the affected gene is needed to cause the disorder. In most cases, the affected gene is located on chromosome 8. However, in some cases, the gene may be located on other chromosomes.

Duane syndrome is caused by mutations in several genes that are involved in eye development. These genes play a role in the formation of the extraocular muscles, which are the muscles that control eye movement. Mutations in these genes can lead to the abnormal development of the extraocular muscles, which can result in Duane syndrome.

Duane syndrome can also be caused by other factors, such as chromosomal abnormalities or environmental factors. However, these causes are much less common than genetic mutations.

Duane syndrome is a complex disorder that is not fully understood. However, research is ongoing to better understand the causes of the disorder and to develop new treatments.