Why are males more likely to have fragile X syndrome?

Males are more likely to have Fragile X syndrome because the gene that causes the condition is located on the X chromosome. Males only have one X chromosome, while females have two. This means that if a male has a mutation on his X chromosome, he will be affected by the condition. In contrast, females would only be affected if both of their X chromosomes have mutations, which is less likely.

Additionally, males have only one copy of the FMR1 gene, which is responsible for producing a protein necessary for normal development. If this gene is mutated or missing, males will have Fragile X syndrome. Females, on the other hand, may have one mutated FMR1 gene and still have the other copy to provide the necessary protein, reducing the likelihood of developing the syndrome.

The Fragile X chromosome is more likely to be unstable and break in males than in females, leading to the full mutation, which causes Fragile X syndrome.