Does marfan syndrome affect life span?

Yes, Marfan syndrome can potentially affect lifespan. While medical advancements and proper management have significantly improved the life expectancy of individuals with Marfan syndrome, it can still shorten a person's lifespan compared to the general population.

The primary life-threatening complication of Marfan syndrome is aortic complications, particularly aortic dissection. Aortic dissection occurs when a tear develops in the inner layer of the aorta, the main artery that carries blood from the heart to the rest of the body. Individuals with Marfan syndrome have weakened aortic tissue due to the genetic defect that affects the production of fibrillin, a protein that provides strength to connective tissue. This weakness makes them more susceptible to aortic dissection, which can be fatal if not promptly treated.

The risk of aortic dissection increases with age, and it is the leading cause of death in people with Marfan syndrome. Early detection and close monitoring of the aorta, along with preventive measures such as medication and regular surveillance, can help reduce the risk of aortic dissection and improve overall life expectancy. However, despite these interventions, the weakened aortic tissue in individuals with Marfan syndrome still carries a higher risk of complications and potential life-threatening events.