What are the chances of a person with adrenoleukodystrophy passing disease to their offspring?

A person with adrenoleukodystrophy (ALD) has a 50% chance of passing the disease to their offspring.

ALD is an X-linked genetic disorder, which means that the gene responsible for the disease is located on the X chromosome. Males have one X chromosome and one Y chromosome, while females have two X chromosomes. This means that males are more likely to be affected by ALD than females, as they only have one copy of the X chromosome.

If a male with ALD has children, all of his sons will be affected by the disease, while all of his daughters will be carriers. If a female with ALD has children, there is a 50% chance that each child will be affected by the disease, regardless of their sex.

There are also some cases of female carriers of ALD who may develop symptoms of the disease later in life. This is known as symptomatic female adrenoleukodystrophy (sALD).