Can a endometrial biopsy be performed during heavy bleeding?

Endometrial biopsies are usually performed during the first half of the menstrual cycle (days 7 to 11) when the uterine lining is optimal for tissue sample collection and to avoid any interference with potential early pregnancy. Endometrial biopsy performed during heavy menstrual bleeding may yield insufficient or less accurate tissue sampling due to the presence of disrupted endometrial tissue.

When heavy menstrual bleeding occurs, it can lead to distortion or dilution of the endometrial tissue, making the interpretation of the biopsy results challenging. Heavy bleeding may also make the procedure more difficult to perform and increase the risk of complications, such as excessive bleeding or infection.

Therefore, it is generally not recommended to perform an endometrial biopsy during heavy bleeding. Instead, it is typically advised to wait until the bleeding has subsided and schedule the procedure during the early part of the menstrual cycle when the endometrial lining is more stable. This allows for a more reliable evaluation of the endometrial tissue and reduces the risk of complications.