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Metformin, PCOS & Weight Loss

Polycystic ovary syndrome affects 4 percent to 10 percent of women of childbearing age. Metformin, a drug originally developed for diabetes, is sometimes used to treat women with PCOS. Studies show that it can restore fertility and assist in weight loss.

  1. Background

    • PCOS is caused by an imbalance in the hormones that trigger ovulation. This can lead to weight gain, infertility and excess facial hair. Women with PCOS frequently have too much insulin in their systems. Insulin helps the body use blood sugar as fuel and convert extra blood sugar into fat.

    Function

    • Metformin makes the body more sensitive to insulin, preventing the body from releasing more insulin than necessary. Metformin also restores the balance of the hormones released by the ovaries.

    Effects

    • Lower insulin levels slow down the cycle of hunger and fat storage, aiding weight loss. This, along with the better balance of hormones released by the ovaries, can increase fertility and help women with PCOS have regular periods.

    Considerations

    • Because Metformin can restore ovulation, women who do not wish to get pregnant should discuss birth-control options with their doctors before taking this drug. The Food and Drug Administration has not approved Metformin for use during pregnancy.

    Warning

    • Metformin's most common side effects are diarrhea and upset stomach, which often go away with time.

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