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5 Facts on Hydroxytryptophan

5-hydroxytryptophan, also known as 5-HTP, is a dietary supplement derived from seeds of the African plant Griffonia simplicifolia. People use 5-HTP as an alternative treatment for many psychological and physical disorders.

  1. Development in the Body

    • The body makes 5-hydroxytryptophan from the amino acid L-tryptophan. L-tryptophan is an essential amino acid, meaning it must be obtained from food because the body cannot create it.

    Serotonin

    • The brain converts 5-hydroxytryptophan to serotonin, a chemical important for regulating mood, behavior, appetite and sleep. Low serotonin levels can lead to impulsive or obsessive behavior, problems with concentration, depression and other difficulties.

    Supplement Purpose

    • People take 5-HTP supplements as an alternative treatment for anxiety, mild to moderate depression, binge eating, attention deficit disorder, chronic headaches, sleep disorders and fibromyalgia.

    Considerations

    • Dr. Ray Sahelian, a physician who writes about natural supplements, notes that 5-hydroxytryptophan supplements are not effective for everyone, possibly because some people's symptoms are not caused by serotonin deficiency.

    Side Effects

    • 5-hydroxytryptophan can increase sensitivity to the sun, so people taking it should use sunscreen and wear protective clothing when outdoors. Taking 5-hydroxytryptophan also may lower sex drive. Doses of 70 mg or higher can cause nausea, vomiting and abdominal cramps.

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