Migraine Treatment With Dihydroergotamine

Dihydroergotamine mesylate is one of the prescription drugs known as ergot alkaloids that are used to treat migraine headaches. It can be given through an IV tube, by intramuscular (IM) or subcutaneous (sub-Q) injection, or via a nasal spray.

Theory

• According to Drugs.com, there are two theories to describe how dihydroergotamine relieves migraine pain. Some experts believe it activates serotonin receptors on blood vessels and constricts the blood flow through those vessels. Others think dihydroergotamine activates serotonin receptors on sensory nerves within the brain and blocks inflammatory chemicals that cause pain.

Indications

• Dihydroergotamine is used to prevent a migraine that has already started. It should not be given to prevent a migraine or to treat non-migraine headaches.

Dose

• The starting dose for dihydroergotamine is 1 mL. This dose can be repeated hourly as needed for migraine pain, to a maximum of 3 mL for IM or sub-Q forms of the drug and to 2 mL for IV forms.

Warning

• Dihydroergotamine can cause serious oxygen deprivation to the brain or extremities if it's taken together with other medications such as cardiac drugs, HIV drugs and antibiotics. It's important to let your doctor know what other medicines you're on if she suggests dihydroergotamine.

Tip

• While you're taking dihydroergotamine, don't drink grapefruit juice because that can interfere with the drug's ability to stop your migraine headache.