Does valvular heart disease caused by fen-phen need to be treated?

Valvular heart disease caused by fen-phen does need to be treated. Fen-phen, a combination of the diet drugs fenfluramine and phentermine, was associated with an increased risk of valvular heart disease, particularly regurgitation of the mitral and aortic valves. While some cases may resolve on their own after stopping the medication, others may require ongoing medical management or even surgical intervention. Treatment decisions depend on the severity and progression of the valve regurgitation and the individual's overall health.